Tomohiro Miyasaka Selected Research

Alzheimer Disease (Alzheimer's Disease)

1/2023	Mass Spectrometry Imaging in Alzheimer's Disease.
1/2022	Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer's disease synapse model.
1/2021	A potential defense mechanism against amyloid deposition in cerebellum.
1/2019	Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry.
1/2018	Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy.
10/2017	Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry.
3/2016	Curcumin improves tau-induced neuronal dysfunction of nematodes.
12/2015	Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.
1/2013	Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.
2/2006	Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).

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Tomohiro Miyasaka Research Topics

Disease

12	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 03/2004
8	Tauopathies 10/2021 - 03/2007
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 07/2014
4	Amyloid Plaque 01/2023 - 10/2017
4	Dementia (Dementias) 01/2022 - 07/2014
4	Parkinson Disease (Parkinson's Disease) 01/2022 - 10/2010
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2023 - 10/2017
2	Hypothermia 12/2007 - 03/2004
1	Asthma (Bronchial Asthma) 03/2024
1	Chronic Obstructive Pulmonary Disease (COPD) 03/2024
1	Inflammation (Inflammations) 03/2024
1	Disease Progression 11/2023
1	Pelizaeus-Merzbacher Disease 01/2023
1	Multiple Sclerosis 01/2023
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2022
1	Multiple System Atrophy 01/2022
1	Synucleinopathies 01/2022
1	Infections 01/2020
1	Frontotemporal Dementia (Semantic Dementia) 10/2019
1	Hypothyroidism 01/2018
1	Lewy Body Disease (Lewy Body Dementia) 01/2016
1	Insulin Resistance 12/2007
1	Diabetes Mellitus 12/2007
1	Glucose Intolerance 12/2007
1	Starvation 03/2004
1	Skin Diseases (Skin Disease) 02/2003
1	Cicatrix (Scar) 01/2003

Drug/Important Bio-Agent (IBA)

4	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2016
4	tau Proteins (tau Protein)IBA 10/2021 - 03/2004
3	Peptides (Polypeptides)IBA 01/2023 - 10/2017
3	Amyloid (Amyloid Fibrils)IBA 01/2021 - 10/2017
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 10/2019 - 08/2005
3	Cysteine (L-Cysteine)FDA Link 12/2015 - 10/2010
2	Therapeutic UsesIBA 11/2023 - 11/2022
2	Amyloid beta-PeptidesIBA 01/2023 - 01/2016
2	formic acid (formate)IBA 01/2023 - 10/2017
2	TubulinIBA 01/2020 - 01/2018
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2007 - 03/2004
2	Insulin (Novolin)FDA Link 12/2007 - 03/2004
1	PapainIBA 03/2024
1	Adrenal Cortex Hormones (Corticosteroids)IBA 03/2024
1	SmokeIBA 03/2024
1	Fixatives (Pickling Agents)IBA 01/2023
1	CuprizoneIBA 01/2023
1	Bouin's solutionIBA 01/2023
1	pyrazoleIBA 11/2022
1	CurcuminIBA 11/2022
1	alpha-SynucleinIBA 01/2022
1	Dynamins (Dynamin)IBA 01/2022
1	LipidsIBA 01/2020
1	Viral HemagglutininsIBA 01/2020
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2020
1	NeurotoxinsIBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018
1	SynucleinsIBA 01/2016
1	Amino Acids FDA Link 10/2015
1	neuromelaninIBA 07/2014
1	Monoclonal AntibodiesIBA 07/2014
1	Presenilin-1IBA 02/2006
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2006
1	Flavin-Adenine Dinucleotide (FAD)IBA 02/2006
1	amyloid beta-protein (1-42)IBA 02/2006
1	Deoxyglucose (2 Deoxy D glucose)IBA 03/2004
1	Glucose (Dextrose)FDA LinkGeneric 03/2004
1	Phosphotransferases (Kinase)IBA 03/2004
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 02/2003

Therapy/Procedure

3	Therapeutics 03/2016 - 03/2007
1	Intraperitoneal Injections 03/2004
1	Electrodes (Electrode) 01/2003
1	Semiconductors 01/2003